SubtiBank SubtiBank
Version comparison:

2020-04-01 14:45:502025-03-15 15:29:30

description

low affinity potassium channel [[protein|KtrC]]-[[protein|KtrD]], peripheric membrane component

glutamate-controlled potassium channel [[protein|KtrC]]-[[protein|KtrD]], peripheric membrane component

product

low affinity potassium channel [[protein|KtrC]]-[[protein|KtrD]], peripheric membrane component

glutamate-controlled potassium channel [[protein|KtrC]]-[[protein|KtrD]], peripheric membrane component

The protein

Kinetic information

the [[protein|KtrC]]-[[protein|KtrD ]]channel has a low affinity for potassium,this is determined by [[protein|KtrD]] [pubmed|30753894]

the [[protein|KtrC]]-[[protein|KtrD ]]channel has a low affinity for potassium, this is determined by [[protein|KtrD]] [pubmed|30753894]

the affinity of [[protein|KtrC]]-[[protein|KtrD]] for potassium is strongly increased in the presence of glutamate (from 0.278 mM to 0.17 mM) [pubmed|32253343]

The protein

Effectors of protein activity

binds ADP and ATP [pubmed|30753894]

the protein binds c-di-AMP, KD = 30 nM, this results in inhibition of potassium uptake [Pubmed|30753894]

binds ADP and ATP [pubmed|30753894]

the protein binds c-di-AMP, KD = 30 nM, this results in inhibition of potassium uptake [Pubmed|30753894]

the affinity of [[protein|KtrC]]-[[protein|KtrD]] for potassium is strongly increased in the presence of glutamate [pubmed|32253343]

labs

[SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]

[SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi Homepage]

[SW|Inga Hänelt], Frankfurt, Germany [https://www.biochem.uni-frankfurt.de/index.php?id=298 Homepage]

[SW|João H Morais-Cabral], University of Porto, Portugal [https://www.i3s.up.pt/research-group?x=47 Homepage]

[SW|Jörg Stülke], University of Göttingen, Germany [http://genmibio.uni-goettingen.de Homepage]

References

Reviews

25869574, 27935846, 25838295, 31361596

25869574, 27935846, 25838295, 31361596, 32472931, 32603625

References

Original publications

12562800, 23671116, 23598340, 28420751, 28504641, 30753894, 31061098, 31506295

12562800, 23671116, 23598340, 28420751, 28504641, 30753894, 31061098, 31506295, 32253343